Analysis of droplet displacement during transport of polydisperse emulsion as drug carriers in microchannels

Abstract Drug transport in human body is often intensified by various carriers. The simplest and highly effective are emulsions. In these liquids, one phase dispersed other the form of droplets, which active substance dissolved. existing application such liquids as carriers, monodispersity systems has been a very important parameter, because when all droplets have same size, it relatively easy to predict drug release time. However, monodisperse emulsion production on an industrial scale expensive technologically quite difficult. Therefore, would be more reasonable use polydisperse mechanism from carriers complicated difficult conduct. When different sizes pass through microchannels, i.e., blood vessels, individual droplets’ velocity interdependent. ability rate at travel microchannels will enable control depending parameters. This work presents detailed analysis single microchannel. Dependence their diameter position relative flow axis influence parameters droplet trajectories were studied. These studies conducted for five liquid rates three concentrations. As result this work, some generalization approach was proposed estimate channel based reference single-phase flow. may find pharmaceutical industry design cheaper manufacturing technologies. Graphical abstract